Green chemistry approaches to the Knoevenagel condensation: comparison of ethanol, water and solvent free (dry grind) approaches

Title: Green chemistry approaches to the Knoevenagel condensation: comparison of ethanol, water and solvent free (dry grind) approaches
Creator: McCluskey, Adam; Robinson, Philip J.; Hill, Tim; Scott, Janet L.; Edwards, J. Kate
Relation: Tetrahedron Letters Vol. 43, Issue 17, p. 3117-3120
Publisher Link: http://dx.doi.org/10.1016/S0040-4039(02)00480-X
Publisher: Elsevier Science Ltd.
Resource Type: journal article
Date: 2002
Description: We report a comparative study of the Knoevenagel condensation with a variety of substituted benzaldehydes (17 examples) and cyanoamides (3 examples), using three different methodologies: (a) traditional ethanol reflux; (b) water reflux; and (c) solvent free conditions. Almost without exception these reactions proceeded faster, more cleanly and in higher yields when the reactions were conducted in a solvent-free fashion. Additionally, our solvent free approach allowed the use of nitrobenzaldehydes, which failed to yield the desired products under traditional and water based approaches.
Subject: Green chemistry; solvent free; Knoevenagel condensations
Identifier: http://hdl.handle.net/1959.13/33615
Identifier: uon:3268
Identifier: ISSN:0040-4039
Language: eng
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